About DHEA-Sulfate
DHEA-Sulfate (dehydroepiandrosterone sulfate) is an endogenous steroid hormone mainly produced by the adrenal glands and is a precursor to both androgens and estrogens. It is the sulfated form of DHEA, which makes it more water soluble and able to circulate in the bloodstream. It plays a role in the development of secondary sexual characteristics and influences a range of physiological functions, including immune response, energy levels, and metabolism.
Reference Values
Optimal Range
≥ 400 µg/dL
Women's Optimal Range
≥ 100.0 µg/dL
Elite Value
Not specified
Health Implications
High
Elevated levels may indicate adrenal gland disorders such as Cushing's syndrome or a potential tumor in the adrenal glands.
Low
Low levels may be associated with conditions such as adrenal insufficiency or hypopituitarism, leading to symptoms of fatigue and weakness.
Symptoms
High
May include acne, excessive hair growth, voice deepening, and menstrual irregularities.
Low
Can include fatigue, mood changes, decreased libido, and weakened bones.
Lifestyle Factors
Specimen Type
Testing Methods
Also Known As
Scientific Sources
- 1. Traish, A. M., Kang, H. P., Saad, F., & Guay, A. T. (2011). Dehydroepiandrosterone (DHEA)—A precursor steroid or an active hormone in human physiology. The Journal of Sexual Medicine, 8(11), 2960-2982.|2. Weiss, E. P., Villareal, D. T., Fontana, L., Han, D. H., Holloszy, J. O., & Klein, S. (2011). Dehydroepiandrosterone (DHEA) replacement therapy in older adults: 2-year effects on body composition and bone mineral density. The Journal of Clinical Endocrinology & Metabolism, 96(2), 486-493.|3. Labrie, F., Bélanger, A., Cusan, L., Gomez, J. L., Candas, B., & Labrie, C. (1997). Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. The Journal of Clinical Endocrinology & Metabolism, 82(8), 2396-2402.|4. Samaras, N., Papadopoulou, M. A., Samaras, D., & Ongaro, F. (2013). Off-label use of hormones as an antiaging strategy: a review. Clinical Interventions in Aging, 8, 117-129.|5. World Health Organization. (2016). Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS). In: WHO Model List of Essential Medicines: 20th List.