About Red Cell Distribution Width (RDW)
Red Cell Distribution Width (RDW) is a measure of the variation in size of red blood cells (RBCs). The RDW is an important parameter within the complete blood count (CBC) test, as it provides information on the morphological variability of erythrocytes, typically reflecting anisocytosis which can be a sign of various hematological and systemic conditions.
Reference Values
Optimal Range
Not specified
Elite Value
Not specified
Health Implications
High
Elevated levels may indicate the presence of conditions like iron deficiency anemia, vitamin B12 deficiency, or chronic inflammatory diseases, potentially leading to increased risk for cardiovascular issues.
Low
Low levels may be associated with less common scenarios but could suggest a patient is undergoing treatment for a condition like anemia or has an underlying marrow pathology.
Symptoms
High
May include fatigue, headaches, shortness of breath, and a pale complexion.
Low
Can include dizziness, weakness, and frequent infections.
Lifestyle Factors
Specimen Type
Testing Methods
Also Known As
Scientific Sources
- Salvagno, G. L., Sanchis-Gomar, F., Picanza, A., & Lippi, G. (2015). Red blood cell distribution width: A simple parameter with multiple clinical applications. Critical Reviews in Clinical Laboratory Sciences, 52(2), 86-105.
- Patel, K. V., Semba, R. D., Ferrucci, L., Newman, A. B., Fried, L. P., Wallace, R. B., & Bandinelli, S. (2010). Red cell distribution width and mortality in older adults: a meta-analysis. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 65(3), 258-265.
- Lippi, G., & Plebani, M. (2014). Red blood cell distribution width (RDW) and human pathology: one size fits all. Clinical Chemistry and Laboratory Medicine, 52(9), 1247-1249.
- Perlstein, T. S., Weuve, J., Pfeffer, M. A., & Beckman, J. A. (2009). Red blood cell distribution width and mortality risk in a community-based prospective cohort. Archives of Internal Medicine, 169(6), 588-594.
- Felker, G. M., Allen, L. A., Pocock, S. J., Shaw, L. K., McMurray, J. J., Pfeffer, M. A., ... & O'Connor, C. M. (2007). Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM program. Circulation, 117(4), 502-508.