About Speed of aging
The 'Speed of aging' biomarker quantifies the rate at which biological aging occurs in the body. It reflects physiological or metabolic changes and predicts age-related health outcomes. This biomarker is derived from various physiological data points and DNA methylation patterns, which are considered reliable indicators of biological aging. It calculates how quickly a person's body is aging compared to the population average.
Reference Values
Health Implications
{'high': 'Elevated levels may indicate a higher risk of chronic diseases such as cardiovascular disease and diabetes, and can lead to deterioration in cognitive function and physical health.', 'low': 'Low levels may be associated with a reduced risk of age-related diseases but could also signify an underlying issue hindering the normal regenerative and repair processes of the body.'}
Symptoms
Lifestyle Factors
Specimen Type
Testing Methods
Scientific Sources
- lsky, D. W., Caspi, A., Houts, R., Cohen, H. J., Corcoran, D. L., Danese, A., Harrington, H., Israel, S., Levine, M. E., Schaefer, J. D., Sugden, K., Williams, B., Yashin, A. I., Poulton, R., & Moffitt, T. E. (2015). Quantification of biological aging in young adults. *Proceedings of the National Academy of Sciences*, 112(30), E4104–E4110.
- lsky, D. W., Caspi, A., Arseneault, L., Baccarelli, A., Corcoran, D. L., Gao, X., Hannon, E., Harrington, H., Houts, R., Huffman, K., Kraus, W. E., Kwon, D., Mill, J., Pieper, C. F., Prinz, J. A., Poulton, R., Schwartz, J., Sugden, K., Vokonas, P., ... Moffitt, T. E. (2020). Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm. *eLife*, 9, e54870.
- eptoe, A., & Zaninotto, P. (2020). Lower socioeconomic status and the acceleration of aging: An outcome-wide analysis. *Proceedings of the National Academy of Sciences*, 117(26), 14911–14917.
- lsky, D. W., Caspi, A., Cohen, H. J., Kraus, W. E., Ramrakha, S., Poulton, R., & Moffitt, T. E. (2017). Impact of early personal-history characteristics on the pace of aging: Implications for clinical trials of therapies to slow aging and extend healthspan. *Aging Cell*, 16(4), 644–651.
- lsky, D. W., Caspi, A., Houts, R., Cohen, H. J., Corcoran, D. L., Danese, A., Harrington, H., Israel, S., Levine, M. E., Schaefer, J. D., Sugden, K., Williams, B., Yashin, A. I., Poulton, R., & Moffitt, T. E. (2015). Quantification of biological aging in young adults. *Proceedings of the National Academy of Sciences*, 112(30), E4104–E4110.